tag:blogger.com,1999:blog-4908756863334307252.post1633997252079869712..comments2024-01-08T14:02:59.211-08:00Comments on Brain Today: Type 2 Diabetes and ADDennis Fortierhttp://www.blogger.com/profile/04495517779435972130noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4908756863334307252.post-34368211127514556412010-01-28T22:28:03.716-08:002010-01-28T22:28:03.716-08:00These are three important papers that demonstrate ...These are three important papers that demonstrate the interaction of IDE and Beta-amyloid. Further studies are underway.<br /><br />Kurochkin IV, Goto S (1994). "Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme". FEBS Lett. 345 (1): 33–7<br /><br />Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S (2003). "Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4162–7.<br /><br />Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE (2007). "Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families". J. Biol. Chem. 282 (11): 7825–32.Michael Rafii, MD, PhDnoreply@blogger.comtag:blogger.com,1999:blog-4908756863334307252.post-85743984298413010042010-01-26T10:30:46.954-08:002010-01-26T10:30:46.954-08:00What was the name of the study that this was taken...What was the name of the study that this was taken from?<br /><br />Has there been any follow-up studies conducted?Alzheimer's Support Canadahttp://www.alzheimers-disease.netnoreply@blogger.com