Could Alzheimer's be Caused by Inflammation?

Contributed by: Dennis Fortier, President, Medical Care Corporation

As with all unsolved scientific problems, hypotheses are constantly developed, modified, and tested with each new study shaping the ongoing debate in some way. In terms of the question "What Causes Alzheimer's?", the hypothesis that inflammation is the culprit has long been discussed and, to some degree, tested in the lab.

The LA Times ran an interesting article this week highlighting the inflammation hypothesis and describing its merits. It's a good overview of a theory that is not considered central by leading thinkers today, but may well have merit.

One quote in the article suggests that this is a "very new" way of thinking about the problem, but that is not really true. Inflammation has been fairly well scrutinized for its role in the Alzheimer's disease process. The current scientific emphasis elsewhere (primarily on the amyloid hypothesis), merely suggests that inflammation is not the most compelling avenue according to most of the experts in the field.

However, most would agree that inflammation may play some role in the complex cascade of pathology associated with this disease.
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1 comment :

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