For some time now, the leading explanation of Alzheimer's disease has been an abnormal accumulation of beta-amyloid in the brain, which leads to cell death and impaired mental function.
While the amyloid hypothesis has been the leading explanation, it has not been universally accepted and is only one of several possible explanations of Alzheimer's pathology. Each time results are released from an FDA trial, researchers scramble to reconcile the results with what is known about treatment targets and the underlying mechanisms of disease progression.
Yesterday's announcement by Eli Lilly that they were canceling development of an agent formulate on the the amyloid hypothesis has reignited discussions about the cause of Alzheimer's disease. A very thorough summary, with cogent, expert commentary from both supporters and detractors, was published today by Bloomberg. This short article provides a balanced view of where the research community stands on the amyloid hypothesis.
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A better understanding and more awareness of Alzheimer's related issues can impact personal health decisions and generate significant impact across a population of aging individuals. Please use the share buttons below to spread this educational message as widely as possible.
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