Showing posts with label Cognitive Impairment. Show all posts
Showing posts with label Cognitive Impairment. Show all posts

Should We Screen Older Adults for Cognitive Impairment?


The US Preventative Services Task Force (USPSTF) recently addressed this question and determined that there is “insufficient evidence to assess the balance of benefits and harms” associated with such screening. In effect, they could not conclude if it was helpful, harmful, or neither.

However, the question, and the conclusion of the USPSTF, both lend themselves to widespread misinterpretation. This brief summary takes a precise look at the issue and offers some clarity.

First of all, the task force defines “screening” in a very specific way. In this case, it means assessing the cognition of  individuals with no clear signs or symptoms of a cognitive deficit. There is essentially no debate that doctors should evaluate the cognitive health of patients who do show signs of impairment; the USPSTF would agree. But “evaluating symptoms” is not the same as “screening” and is therefore, not a part of this discussion.


Assessing subjects with no symptoms is “screening” while assessing subjects who do have symptoms is “case finding”. This USTFPS opinion relates strictly to screening.

Second, the term cognitive impairment covers a wide range of disability from very mild (a subtle sense that thinking skills are becoming slower or less vital) to severe (full dementia including a loss of ability to care for oneself). The broad range of severity in this definition is problematic because, as just discussed, the term “screening” only applies to those “older adults” at the extreme mild end of this spectrum. As such, the posed question contains an inherent flaw. Either “screening” is the wrong word because it does not apply to many along the spectrum of cognitive impairment, or the term “cognitive impairment” must be precisely qualified to include only asymptomatic subjects. Otherwise, a sensible answer cannot be derived.

Finally, this discussion is further complicated by the fact that the publications, upon which the USPSTF based their conclusion, evaluated only cognitive assessment instruments designed to detect “dementia”, not the asymptomatic subjects contemplated by the notion of screening. Therefore, an evaluation of the benefits and harms of screening older adults for the full range of cognitive impairment, based on instruments that reliably detect only the most severely impaired, is neither comprehensive nor conclusive.

The bottom line, as emphasized in the accompanying editorials to the USPSTF recommendations published in JAMA, is that wide scale screening of asymptomatic populations over age 65 is not yet warranted by published evidence, but it certainly has strong theoretical appeal. 

The USPSTF’s conclusion of “insufficient evidence” should not be interpreted as a recommendation against screening, rather, it is a factual statement about the paucity of studies that have been published in this area. But it should be noted that Medicare mandates the “identification of cognitive impairment” during Welcome to Medicare exams. So when asking if we should screen older adults for cognitive impairment, at least one well-informed branch of government believes that the benefits outweigh the costs.

Screening for Cognitive Impairment

Contributed by: Dennis Fortier, President, Medical Care Corporation
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Yesterday, the U.S. Preventative Services Task Force (USPSTF) ruled that there is insufficient evidence to make a recommendation, either for or against, routine screening for cognitive impairment in older adults. Today, the press is ablaze with sloppy reporting on the matter.

Many news stories (like this from US News and World Report) are conflating cognitive impairment with dementia, but readers of this blog understand that cognitive impairment may be very mild whereas dementia is, by definition  a severe loss of cognitive capacity. Many others (like this from Time), are interchanging dementia and Alzheimer's disease, which inappropriately implies that the two are one in the same, and obscures the fact that Alzheimer's is but one of the many causes of dementia.

To be clear, the USPSTF did not rule against anything. They merely concluded that the evidence is not strong enough to make a recommendation one way or the other. More importantly, their ruling was related to "screening" of "older adults" for "cognitive impairment". In other words, should the healthcare system invest in regular cognitive assessment of all older adults, whether they suspect a problem or not? Their conclusion? They're not sure.  They're not for it and not against it.

Rather, the public should monitor their cognitive health vigilantly and promptly report concerns to their physicians for a thorough evaluation. This will allow early intervention against treatable problems like thyroid dysfunction, vitamin deficiency, anxiety/depression, sleep disorders, and out of control diabetes, all known contributors to cognitive deficits. It will also facilitate early diagnosis of Alzheimer's disease.

This is important because Alzheimer's can be effectively managed for a significant percentage of patients. Effective management of Alzheimer's includes early diagnosis, physical exercise, proper diet, strict control of hypertension and diabetes, poly-therapy with a cholinesterase inhibitor and Namenda, ongoing social and intellectual stimulation, and caregiver education. All of these interventions have been shown to promote optimal disease management and, when brought together as a robust therapeutic regimen, can be surprisingly effective.

6 Ways to Prevent Memory Loss

Contributed by: Dennis Fortier, President, Medical Care Corporation
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This summary, published online today at Fox News, cites evidence supporting 6 lifestyle choices you can make to reduce the likelihood of cognitive decline.

Of course, there are no guarantees and bad genes combined with age can overwhelm even the best life-style.  Nonetheless, it is worthwhile to know the steps that might help, and to pursue as many of them as possible.

I suggest you click through and read the short story, but here is the list:
  1. Stay Physically Active
  2. Eat Fruits and Veggies
  3. Reduce Risk Factors for Heart Disease
  4. Embrace Cultural Activities
  5. Care for Your Teeth
  6. Challenge your Intellect
Remember, there is no certain method to eliminate all risk of cognitive decline, but doing what you can to stack the odds in your own favor seems like an attractive course of action.

Want a Healthy Brain? Stay Physically Active.

Contributed by: Dennis Fortier, President, Medical Care Corporation
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There are no guarantees, but this is our current best bet.  The evidence linking physical fitness to good cognitive health in later life continues to roll in.

At the International Conference on Alzheimer's Disease in July, researchers from the University of California, San Francisco presented data showing the high correlation between physical fitness and brain health.  Their research on "modifiable risk factors", or lifestyle changes we are all free to make, showed that regular activity was the most likely to reduce the risk of cognitive decline.

Importantly, several of the other risk factors that are highly correlated with cognitive decline, may also be reduced through physical activity.  Hypertension, obesity, diabetes, and even depression, all of which confer higher risk of cognitive decline, can be managed to some degree through regular physical exercise.

We have known for some time that staying active is good for our hearts and it has always made sense that a regular supply of oxygen-rich blood is probably good for our brains.  This latest research is more evidence that it is likely to be true.

Medicare Coverage for Detecting Cognitive Impairment

Contributed by: Dennis Fortier, President, Medical Care Corporation
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One of the constant themes of this blog is that Alzheimer's disease is routinely detected too late in today's medical environment. The data show that diagnoses are most common in years 8-10 of a typical disease course that runs 14 years. This means that the opportunity for treatment during years 1 through 7, when the brain is still quite healthy, is lost.

This practice of "late intervention" manifests itself in many of our blog topics. It contributes to the impression that treatment is completely ineffective when, in fact, earlier intervention can lead to meaningful delay of disease progression for some patients. Late intervention not only mitigates treatment effect but drives up health care costs because patients with impaired thinking do not practice effective self care. Also, late intervention has fueled the misdirected belief that Alzheimer's and dementia are one in the same. Sure, a person with Alzheimer's pathology will eventually become demented, but there is a long period of disease progression when the patient has only subtle cognitive difficulties.

As we have written, there are some understandable reasons why we intervene late. However, with the Health Care Reform Act passed in March and clarified last week, this could soon change.

Beginning in January of 2011, Medicare will reimburse primary care physicians to perform a more complete "Welcome to Medicare" visit with newly eligible members. They will also pay physicians to perform a complete "Wellness Visit" on an annual basis. Both the welcome visit and the wellness visit will include "detection of cognitive impairment".

This is a great step in the right direction. It will force a conversation between patients and doctors that has been sorely needed but ignored for some time. I know that not every Medicare recipient will schedule these visits and not every physician will follow all of the guidelines. In fact, I suspect only a small percentage of those on Medicare will actually have their cognition assessed in 2011. But I predict an overwhelmingly clear picture will emerge from this "toe in the door" to better care.

Here is what I envision: Some physicians will take this opportunity seriously and perform careful assessments of their patients. Some of their "seemingly healthy" patients will perform poorly on a simple cognitive test and a diagnostic work-up will ensue. The physician will find and treat a range of memory-impairing medical problems from depression to thyroid disorder to early Alzheimer's disease. Overall, patients will benefit from treatment of these conditions and their cognition will improve. As their minds become sharper than they would have been without treatment, they will do a better job managing their hypertension and their diabetes. They will be less depressed; they will feel better and stay more active. Their overall health will improve and the cost to Medicare for keeping them healthy will plummet.

Such an ideal will never be achieved in an entire population. However, I believe that the impact of such care on even a small scale will be discernible in the data. If so, then each year, more and more physicians and a growing number of patients will embrace the concept of managing their cognitive health. I think we are finally on the right track.

7 Facts about Stroke and Cognitive Impairment

Contributed by: Dennis Fortier, President, Medical Care Corporation
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Each year, about 700,000 people in the USA suffer a stroke. While it is certainly true that stroke can be deadly, it is the third leading cause of death behind heart disease and cancer, it can also cause significant cognitive changes in those who survive.

These changes may be subtle and cause mild cognitive impairment or they may be more severe resulting in dementia. Following are 7 interesting facts to help you better understand the impact of stroke.

1. While stroke is the third leading cause of death, it is the second most common cause of cognitive impairment and dementia.

2. Even damage to a small portion of the brain can have serious consequences. In fact, a thimble full of damaged brain due to stroke can cause dementia.

3. Stroke begins after age 50 and can gradually build up in the brain for decades. This gradual accumulation of tiny strokes can interfere progressively with the brain’s function until the individual becomes demented.

4. The risk of developing cognitive impairment is highest in those persons with vascular risk factors. These factors include:
  • High Blood Pressure or Low Blood Pressure
  • High Cholesterol
  • Obesity
  • Diabetes
  • Atherosclerosis (hardening of the arteries)
  • Minimal physical exercise (less than 2 days/week and 30 mins/session)
  • Smoking
  • Alcohol dependence
  • Prior stroke.
5. The most common types of cognitive problems due to are disturbances of attention, language, memory and executive function. Executive function is the ability to analyze, interpret, plan, organize, and execute complex instructions.

6. The risk of cognitive impairment and dementia, as well as the rate of cognitive decline in cerebrovascular disease, is highly correlated with underlying risk factors for stroke.

7. If left untreated, vascular cognitive impairment and dementia worsen. Annual screening for cognitive impairment in attention, memory and executive function starting at age 50 will help detect gradually accumulating cerebrovascular disease that may otherwise typically be undetected for many years.

A good additional source of information about risks for dementia is PreventAD.com. The site is sponsored by Medical Care Corporation but, like this blog, it is non-commercial and seeks only to educate. This content about stroke was a popular article from a past issue of Ounce of Prevention, the newsletter associated with that site.

Does Surgery Cause Memory Loss?

Contributed by: Dennis Fortier, President, Medical Care Corporation
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Sometimes there are contradictions between anecdotal evidence and scientific evidence. Even when the two are aligned, there is often a disconnect between the published evidence and the way it is reported in the lay press. Such is the case with the seeming correlation between surgery and memory loss.

A recently published study in Anesthesiology, did not contradict the widespread sense that memory loss is a common consequence of surgery but some of the press coverage indicated that it did. As you can see, the story to which this posting is linked opens with the statement that researchers found "no post-surgical issues in older patients". However, it is clear in the publication (and even from the rest of the story) that there were indeed two areas of concern.

First, in patients who did not recover well physically from the surgical procedure, lingering cognitive issues were indeed present. That is essentially a confirmation of the link between surgery and cognitive impairment.

Second, even among those patients who had complete physical recoveries, cognition was not always fully restored until a period of six months to a year later. To suggest that anything short of a permanent disability should be ignored is not really a defensible approach to reporting this science.

Both of these findings are perfectly consistent with the anecdotal belief that cognition is sometimes impaired following a surgical procedure. It is unclear why the author of this article chose to open with a contradictory position but should serve as a reminder to readers that scientific research must be carefully interpreted and many journalists do not exercise care when reporting on new findings.

7 Facts about Stroke and Cognitive Impairment

Contributed by: Dennis Fortier, President, Medical Care Corporation
________________________________________________

A good source of information about risks for dementia is PreventAD.com. The site is sponsored by Medical Care Corporation but, like this blog, it is non-commercial and seeks only to educate. This content about stroke was a popular article from a past issue of Ounce of Prevention, the newsletter associated with that site.

Stroke is the third leading cause of death, behind heart disease and cancer. Each year, about 700,000 people suffer a stroke. Stroke can be a cause of dementia and cognitive impairment.

The following are 7 interesting facts about stroke and cognitive impairment.

1. Stroke is the second most common cause of cognitive impairment and dementia.

2. A thimble full of damaged brain due to stroke can cause dementia.

3. Stroke begins after age 50 and can gradually build up in the brain for decades. This gradual accumulation of tiny strokes progressively interferes with the brain’s function until the individual end’s up demented.

4. The risk of developing cognitive impairment is highest in those persons with vascular risk factors, including hypertension, hyperlipidemia, atherosclerotic vessel disease affecting the aorta, carotid, vertebrobasilar, or major cerebral arteries, homocysteinemia, diabetes, heart disease, hypotension, obesity, physical exercise less than two days per week and 30 minutes per session, smoking, alcohol dependence, coagulopathies, and prior stroke.

5. The most common types of cognitive deficits arising from stroke are disturbances of attention, language syntax, delayed recall and executive dysfunction affecting the ability to analyze, interpret, plan, organize, and execute complex information.

6. The risk of vascular cognitive impairment and dementia as well as the rate of cognitive decline in cerebrovascular disease is highly dependent upon the control of the underlying risk factors for stroke.

7. If left untreated, vascular cognitive impairment and dementia worsen. Annual screening for cognitive impairment in attention, memory and executive function starting at age 50 years old will help detect gradually accumulating cerebrovascular disease that may otherwise typically be undetected for many years.

NFL Players at High Risk for Dementia


Contributed by: Dennis Fortier, President, Medical Care Corporation
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This is not surprising. Such a conclusion is perfectly consistent with our best theories as well as our casual observations. The fact that persons with a history of head trauma have greater risk for dementia is well documented and the connection to the NFL has been highly speculated for some time.

Now, as reported in the NY Times, the NFL has released the results of their own study on the matter. As part of a phone survey conducted by the University of Michigan's Institute for Social Research last year, 1,063 retired NFL players were asked questions on a variety of health topics. The conclusions were stark, especially for younger aged retirees.

According to the survey, 6.1% of players aged 50 and older had cognitive impairment which is five times higher than the 1.2% rate of prevalence in the general population. More importantly, 1.9% of younger players, aged 30 to 49, had impairment which is nineteen times higher than the .1% rate seen in general.

These figures are even more alarming than many experts would have presumed and will undoubtedly raise new questions about the prudence of suiting up 9-year olds and sending them onto the little league field to bang heads. I love football as much as anyone but it is looking more and more like the costs of the game are greater than the enjoyment it provides.

7 Facts About Stroke and Cognitive Impairment

Contributed by: Dennis Fortier, President, Medical Care Corporation
________________________________________________

A good source of information about risks for dementia is PreventAD.com. The site is sponsored by Medical Care Corporation but, like this blog, it is non-commercial and seeks only to educate. This content about stroke was a popular article from a past issue of Ounce of Prevention, the newsletter associated with that site.

Stroke is the third leading cause of death, behind heart disease and cancer. Each year, about 700,000 people suffer a stroke. Stroke can be a cause of dementia and cognitive impairment.

The following are 7 interesting facts about stroke and cognitive impairment.

1. Stroke is the second most common cause of cognitive impairment and dementia.

2. A thimble full of damaged brain due to stroke can cause dementia.

3. Stroke begins after age 50 and can gradually build up in the brain for decades. This gradual accumulation of tiny strokes progressively interferes with the brain’s function until the individual end’s up demented.

4. The risk of developing cognitive impairment is highest in those persons with vascular risk factors, including hypertension, hyperlipidemia, atherosclerotic vessel disease affecting the aorta, carotid, vertebrobasilar, or major cerebral arteries, homocysteinemia, diabetes, heart disease, hypotension, obesity, physical exercise less than two days per week and 30 minutes per session, smoking, alcohol dependence, coagulopathies, and prior stroke.

5. The most common types of cognitive deficits arising from stroke are disturbances of attention, language syntax, delayed recall and executive dysfunction affecting the ability to analyze, interpret, plan, organize, and execute complex information.

6. The risk of vascular cognitive impairment and dementia as well as the rate of cognitive decline in cerebrovascular disease is highly dependent upon the control of the underlying risk factors for stroke.

7. If left untreated, vascular cognitive impairment and dementia worsen. Annual screening for cognitive impairment in attention, memory and executive function starting at age 50 years old will help detect gradually accumulating cerebrovascular disease that may otherwise typically be undetected for many years.